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New perspectives in the renin-angiotensin-aldosterone system (RAAS) I: endogenous angiotensin converting enzyme (ACE) inhibition.

PLoS One.. 2014-04;  9(4)
Fagyas M, Uri K, Siket IM, DaragÓ A, BoczÁn J, BÁnyai E, Edes I, Papp Z, TÓth A. Affiliation: Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Debrecen, Hungary.
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摘要

Angiotensin-converting enzyme (ACE) inhibitors represent the fifth most often prescribed drugs. ACE inhibitors decrease 5-year mortality by approximately one-fifth in cardiovascular patients. Surprisingly, there are reports dating back to 1979 suggesting the existence of endogenous ACE inhibitors, which endogenous inhibitory effects are much less characterized than that for the clinically administered ACE inhibitors. Here we aimed to investigate this endogenous ACE inhibition in human sera. It was hypothesized that ACE activity is masked by an endogenous inhibitor, which dissociates from the ACE when its concentration decreases upon dilution. ACE activity was measured by FAPGG hydrolysis first. The specific (di... More

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