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Photo-Responsive Decellularized Small Intestine Submucosa Hydrogels

Advanced Functional Materials. 2024-04; 
Van Thuy Duong, Han Dang Nguyen, Ngoc Ha Luong, Chun-Yi Chang, Chien-Chi Lin
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Peptide Synthesis C-terminal Cysteine residue added for orthogonal thiol-norbornene conjugation) was custom synthesized and purified to at least 85% purity by GenScript Biotech.  Get A Quote

摘要

Decellularized small intestine submucosa (dSIS) is a promising biomaterial for promoting tissue regeneration. Isolated from the submucosal layer of animal jejunum, SIS is rich in extracellular matrix (ECM) proteins, including collagen, laminin, and fibronectin. Following mild decellularization, dSIS becomes an acellular matrix that supports cell adhesion, proliferation, and differentiation. Conventional dSIS matrix is usually obtained by thermal crosslinking, which yields a soft scaffold with low stability. To address these challenges, dSIS is modified with methacrylate groups for photocrosslinking into stable hydrogels. However, dSIS has not been modified with clickable handles for orthogonal crosslinking. Her... More

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