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Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside

Front Immunol. 2024-02; 
Julia Heinzelbecker, Marte Fauskanger, Ida Jonson, Ute Krengel, Geir Åge Løset, Ludvig Munthe, Anders Tveita
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Gene Synthesis … gene synthesis (Genscript Biotech Corp, NJ, USA) and inserted into the periplasmic expression vector pHOG (13). Expression and purification of scFv fragments were performed as … Get A Quote

摘要

Chimeric antigen receptor (CAR) T cell technology has ushered in a new era of immunotherapy, enabling the targeting of a broad range of surface antigens, surpassing the limitations of traditional T cell epitopes. Despite the wide range of non-protein tumor-associated antigens, the advancement in crafting CAR T cells for these targets has been limited. Owing to an evolutionary defect in the CMP-Neu5Ac hydroxylase (CMAH) that abolishes the synthesis of CMP-Neu5Gc from CMP-Neu5Ac, Neu5Gc is generally absent in human tissues. Despite this, Neu5Gc-containing antigens, including the ganglioside GM3(Neu5Gc) have consistently been observed on tumor cells across a variety of human malignancies. This restricted expressio... More

关键词

14F7, CAR (chimeric antigen receptor) T cells, GM3(Neu5Gc) ganglioside, antibody, carbohydrate antigen, immunotherapy, solid tumor
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