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HERPUD1 governs tumor cell mitochondrial function via inositol 1,4,5-trisphosphate receptor-mediated calcium signaling

Free Radic Biol Med. 2023-12; 
Felipe Paredes, Mario Navarro-Marquez, Clara Quiroga, Danica Jiménez-Gallegos, Samantha M Yeligar, Valentina Parra, Marioly Müller, Mario Chiong, Andrew F G Quest, Alejandra San Martin, Sergio Lavandero
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Proteins, Expression, Isolation and Analysis … Protein samples were separated on Express-Plus Page Gels (GenScript) with Tris-MOPS buffer containing SDS and transferred onto Immobilon-P membrane (Millipore, IPVH00010). All … Get A Quote

摘要

The intricate relationship between calcium (Ca) homeostasis and mitochondrial function is crucial for cellular metabolic adaptation in tumor cells. Ca-initiated signaling maintains mitochondrial respiratory capacity and ATP synthesis, influencing critical cellular processes in cancer development. Previous studies by our group have shown that the homocysteine-inducible ER Protein with Ubiquitin-Like Domain 1 (HERPUD1) regulates inositol 1,4,5-trisphosphate receptor (ITPR3) levels and intracellular Ca signals in tumor cells. This study explores the role of HERPUD1 in regulating mitochondrial function and tumor cell migration by controlling ITPR3-dependent Ca signals. We found HERPUD1 levels correlated with mitoch... More

关键词

Calcium, HERPUD1, IP3 receptor, Mitochondria, Oxidative stress, Tumoral cell
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