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Changes in Gene Chromatin Organization during Odontogenic Lineage Specification

Genes (Basel). 2023-01; 
Gokul Gopinathan, Xinmin Zhang, Xianghong Luan, Thomas G H Diekwisch
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Gene Synthesis … development and a preliminary assessment of the consequences of aberrant HOX gene activation during mandibular development… and Cdx4 were obtained from Genscript. O9-1 mouse … Get A Quote

摘要

Craniofacial tissues comprise highly evolved organs characterized by a relative lack of expression in the HOX family transcription factors. In the present study, we sought to define the epigenetic events that limit gene expression from undifferentiated neural crest cells to semi-differentiated odontogenic progenitors and to explore the effects of elevated levels of . The ChIP-chip data demonstrated high levels of repressive H3K27me3 marks on the gene promoters in ES and cranial neural crest cells when compared to the H3K4me3 marks, while the K4/K27 ratio was less repressive in the odontogenic progenitors, dental follicle, dental pulp, periodontal ligament fibroblasts, alveolar bone osteoblasts, and cementobla... More

关键词

EZH2, Hox genes, craniofacial, epigenetic, histone methylation, neural crest, odontogenic
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