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Rearranged endogenized plant pararetroviruses as evidence of heritable RNA-based immunity

Mol Biol Evol. 2022-11; 
Adrian A Valli, Irene Gonzalo-Magro, Diego H Sanchez
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摘要

Eukaryotic genomics frequently revealed historical spontaneous endogenization events of external invading nucleic acids, such as viral elements. In plants, an extensive occurrence of endogenous plant pararetroviruses (EPRVs) is usually believed to endow hosts with an additional layer of internal suppressive weaponry. However, an actual demonstration of this activity remains speculative. We analysed the EPRV component and accompanying silencing effectors of Solanum lycopersicum, documenting that intronic/intergenic pararetroviral integrations -bearing inverted-repeats- fuel the plant's RNA-based immune system with suitable transcripts capable of evoking a silencing response. A surprisingly small set of rearrange... More

关键词

Caulimoviridae, Solanum, EPRVs, PTGS, RNA interference, endogenized pararetrovirus, epigenetic silencing, epigenetics, introns, long non-coding RNA, pararetrovirus, post transcriptional gene silencing, siRNA, tomato
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