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The determination for the three genotypes of D16S539 locus based on near-infrared spectroscopy and chemical pattern recognition.

Am J Pathol.. 2009-04;  638(2):202-8
Ren L, Gao YZ, Yin JH, Shi WX, Yu XW, Xie HP, Wang WP. a College of Pharmaceutical Sciences, Soochow University, No. 199 Ren-ai Road, Dushu Lake Higher Education Town, Suzhou 215123, PR Chinab Department of Forensic Medicine, Medical School, Soochow University, Suzhou 215123, PR China
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摘要

The paper has established an approach of typing short tandem repeats (STRs) based on the near-infrared spectroscopy (NIRS)–chemical pattern recognition. Taking the three genotypes 9-9, 9-11 and 11-11 of D16S539 locus as example, which have a middle degree of difference, DNA fragments containing the polymorphism sites were amplified by a pair of primers to obtain three genotypes samples; these samples were tested by the NIRS directly; using their spectra as recognition variables, the chemical pattern recognition models of the three genotypes were respectively established by using the principal discriminant variate (PDV) and support vector machine (SVM). The two models have a good fitting ability and strong... More

关键词

Short tandem repeats; Near-infrared spectroscopy; Chemical pattern recognition; Principal discriminant variate; Support vector machine
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