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Effects of α-melanocortin enantiomers on acetaminophen-induced hepatotoxicity in CBA mice.

Molecules.. 2009-12;  14(12):5017-26
Turcic P, Bradamante M, Houra K, Stambuk N, Kelava T, Konjevoda P, Kazazic S, Vikic-Topic D, Pokric B. Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Domagojeva 2, 10000 Zagreb, Croatia
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摘要

Proteins and peptides in mammals are based exclusively on L-amino acids. Recent investigations show that D-amino acids exhibit physiological effects in vivo, despite of their very small quantities. We have investigated the hepatoprotective effects of the Land D-enantiomers of alpha-melanocortin peptide (alpha-MSH). The results showed that peptide-enantiomerism is related to the protective effects of melanocortin peptides in vivo. L-alpha-MSH exhibited potent hepatoprotective effect in the experimental model of acetaminophen induced hepatotoxicity in male CBA mice, while its D-mirror image was inefficient. Furthermore, the antibody to the L-peptide did not recognize the D-structure. The results indicate that the... More

关键词

enantiomer; α-MSH; hepatoprotection; hepatotoxicity; antibody; CD spectroscopy
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