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Chinese Herbal Complex 'Bu Shen Jie Du Fang' (BSJDF) Modulated Autophagy in an MPP-Induced Cell Model of Parkinson's Disease.

Evid Based Complement Alternat Med. 2019; 
LiuCuifang,HuangXiaobo,QiuShengxiang,ChenWenqiang,LiWeihong,ZhangHaiyan,WangTao,WangXue,WuXi
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Proteins, Expression, Isolation and Analysis … We examined the neuroprotective effects of BSJDF by PCM, hemocytometer, and CCK-8. And autophagic process was visualized using TEM … ExpressPlus PAGE Gels and Tris-MOPS-SDS Running Buffer Powder were purchased from GenScript (Nanjing, China) … Get A Quote

摘要

Autophagy plays an important role in the development of Parkinson disease (PD). Previous studies showed that autophagy could protect cells from -synuclein toxicity and promote functional coupling of mitochondria. But it is still a question whether modulating autophagy can be used to treat PD. In traditional Chinese medicine, a specific Chinese herbal complex called Bu Shen Jie Du Fang (BSJDF) has a long history of treating motor impairments similar to Parkinson disease, while its mechanism is still unclear. As a pilot study, we aimed to evaluate the efficacy and its mechanism of Bu Shen Jie Du Fang in an MPP-induced cell model of Parkinson's disease. And the phase contrast microscope (PCM) revealed that t... More

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