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A Quantitative Point-of-Need Assay for the Assessment of Vitamin D Deficiency.

Sci Rep. 2017-10; 
VemulapatiS, ReyE, O'DellD, MehtaS, Erick
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Catalog Antibody … 12 ). Materials and Methods. The monoclonal anti-25(OH)D 3 IgG produced in mouse (GenScript Inc) was conjugated with 40 nm Gold Nanoparticles using the InnovaCoat Gold Conjugation Kit (Innova Biosciences Ltd). For … Get A Quote

摘要

Vitamin D is necessary for the healthy growth and development of bone and muscle. Vitamin D deficiency, which is present in 42% of the US population, is often undiagnosed as symptoms may not manifest for several years and long-term deficiency has been linked to osteoporosis, diabetes and cancer. Currently the majority of vitamin D testing is performed in large-scale commercial laboratories which have high operational costs and long times-to-result. Development of a low-cost point-of-need assay could be transformative to deficiency analysis in limited-resource settings. The best biomarker of vitamin D status, 25hydroxyvitamin D (25(OH)D), however, is particularly challenging to measure in such a form... More

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