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Monocyte Stabilin-1 Suppresses the Activation of Th1 Lymphocytes.

J Immunol.. 2016-01; 
Palani S, Elima K, Ekholm E, Jalkanen S, Salmi M.
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Gene Synthesis ... F(ab)2 fragments of 9-11 and MEL-14 were generated commercially by GenScript. Immunofluorescence stainings and FACS analyses Blood samples were collected in EDTA tubes. RBCs were lysed using a commercial lysis buffer (BD Pharm Lyse; BD Biosciences). ... Get A Quote

摘要

In this study, we analyzed the putative functions of stabilin-1 in blood monocytes. Microarray analysis revealed downregulation of several proinflammatory genes in the stabilin-1(high) monocytes when compared with stabilin-1(low) monocytes. When cocultured with stabilin-1(high) monocytes, IFN-γ synthesis by T cells was diminished in Ag-recall assays. Knockdown of stabilin-1 in monocytes increased the synthesis of several proinflammatory molecules, including TNF-α, and supported high IFN-γ and low IL-4 and IL-5 production by T cells in Ag-specific stimulation assays. Anti-stabilin-1 Ab treatment also led to increased IFN-γ synthesis in the recall assays. In clinical settings, the expression of stabilin-1 was... More

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