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href=\"\/\/m.wivlo.com\/webinars\/mRNA-Immunization-for-transmembrane-protein-antibody-discovery.html\">","content":"{literal}\n<style type=\"text\/css\">\n.blog-content-flex {\n    position: relative;\n    display: flex;\n    flex-flow: wrap;\n    justify-content: space-between;\n}\n.post-region{\nwidth:30%;\n}\n\n@media only screen and (max-width:767px) {\n\n.post-region{\nwidth:100%;\nmargin-bottom:10px;\n}\n}\n<\/style>\n{\/literal}\n<div class=\"webinars-main clearfix\">\n\t<article class=\"webinars-l\">\n\t\t<div class=\"webinars-full\">\n\t\t\t<h1>\u591a\u6b21\u8de8\u819c\u86cb\u767d\u9776\u70b9\u7684\u6297\u4f53\u5236\u5907\u65b0\u7b56\u7565\uff1amRNA\u514d\u75ab\u6280\u672f<\/h1>\n\t\t\t<p>\u591a\u6b21\u8de8\u819c\u86cb\u767d\u7531\u4e8e\u5176\u7ed3\u6784\u590d\u6742\u3001\u86cb\u767d\u6eb6\u89e3\u5ea6\u4f4e\u4e14\u7eaf\u5316\u96be\u7b49\u539f\u56e0\uff0c\u5728\u6297\u4f53\u5f00\u53d1\u65f6\u987b\u8c28\u614e\u9009\u62e9\u9002\u5b9c\u7684\u6280\u672f\u7b56\u7565\u3002\u4e0e\u4ee5DNA\u3001\u86cb\u767d\u3001\u591a\u80bd\u7b49\u7269\u8d28\u4e3a\u514d\u75ab\u539f\u7684\u5e38\u89c4\u6297\u4f53\u5f00\u53d1\u7b56\u7565\u76f8\u6bd4\uff0cmRNA\u514d\u75ab\u6280\u672f\u62e5\u6709\u7ec6\u80de\u8d28\u4e2dmRNA\u53ef\u76f4\u63a5\u7ffb\u8bd1\u3001\u80fd\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u81ea\u53d1\u8fdb\u884c\u86cb\u767dPTM\uff0c\u65e0\u9700\u4f50\u5242\u5373\u53ef\u83b7\u5f97\u81ea\u7136\u6784\u8c61\u7b49\u4f18\u52bf\uff0c\u53ef\u5728\u66f4\u77ed\u65f6\u95f4\u5185\uff0c\u5236\u5907\u7075\u654f\u5ea6\u9ad8\u3001\u7279\u5f02\u6027\u5f3a\u7684\u591a\u6b21\u8de8\u819c\u86cb\u767d\u9776\u70b9\u7684\u6297\u4f53\u3002\n<\/p>\n\t\t\t \n<a class=\"anchor\" name=\"video\"><\/a>\n<h2>\u8bfe\u7a0b\u5185\u5bb9\u4eae\u70b9\uff1a<\/h2> \n<ul class=\"tableul tableol\">\n<li>\u9488\u5bf9\u591a\u6b21\u8de8\u819c\u86cb\u767d\u6297\u4f53\u7684\u5f00\u53d1\u96be\u70b9\u4e0e\u7814\u7a76\u8fdb\u5c55 <\/li>\n<li>mRNA\u514d\u75ab\u6280\u672f\u7528\u4e8e\u591a\u6b21\u8de8\u819c\u86cb\u767d\u8bca\u65ad\/\u6cbb\u7597\u9886\u57df\u7684\u5e94\u7528\u4f18\u52bf<\/li>\n<li>mRNA\u514d\u75ab\u7528\u4e8e\u6297\u4f53\u5f00\u53d1\u7684\u7b56\u7565\u53ca\u6848\u4f8b\u5206\u4eab<\/li> \n<\/ul> \n<div class=\"h20\"><\/div>\n<div class=\"h20\"><\/div>\n<div class=\"module-center\"> \n\t\t\t\t<iframe class=\"iframe-size\"   src=\"\/\/player.bilibili.com\/player.html?aid=831153856&bvid=BV1f34y1P7K3&cid=1274270143&p=1\" scrolling=\"no\" border=\"0\" frameborder=\"no\" framespacing=\"0\" allowfullscreen=\"true\"> <\/iframe> \n<a href=\"\/customer\/login?return=\/webinars\/mRNA-Immunization-for-transmembrane-protein-antibody-discovery.html\" class=\"vedio iframe-vedio btn-download-2\"><\/a>\n\t\t\t<\/div>\n\n<div class=\"h10\"><\/div>\n\t\t\t<div class=\"webinardl\" style=\"overflow:hidden\">\n\t\t\t\t<hr\/>\n\t\t\t\t <img src=\"\/gsimages\/webinar\/mRNA-Immunization-for-transmembrane-protein-antibody-discovery-speaker.jpg\" style=\"max-width:130px;border-radius:50%;margin-bottom:0\" class=\"floatR ifn\"> \n\t\t\t\t<dl>\n<dt>  <strong class=\"font16\" >\u8bfe\u7a0b\u5185\u5bb9\uff1a(<a href=\"\/location?href=\/gsfiles\/techfiles\/webinar\/GenScript_mRNA_Immunization_for_transmembrane_protein_antibody_discovery.pdf\">\u70b9\u51fb\u4e0b\u8f7d\u8bfe\u4ef6<\/a>\uff09<\/strong> <\/dt>\n\t\t\t\t\t<dt><strong class=\"font16\" >\u4e3b\u8bb2\u4eba\uff1a<\/strong> \u8096\u5a77\u5a77\u535a\u58eb \u91d1\u65af\u745e\u6297\u4f53\u9ad8\u7ea7\u79d1\u5b66\u5bb6  <\/dt> \n<dt><strong class=\"font16\" >\u4e3b\u8bb2\u4eba\u4ecb\u7ecd\uff1a<\/strong><\/dt>\n <dd>\n\n<ul class=\"tableul\">\n    <li>\u535a\u58eb\u6bd5\u4e1a\u4e8e\u9999\u6e2f\u5927\u5b66\uff0c\u535a\u58eb\u671f\u95f4\u72ec\u7acb\u6267\u884c\u9999\u6e2f\u57fa\u91d1\u59d4RGC\u7814\u7a76\u9879\u76ee(94\u4e07\u6e2f\u5e01)\u5e76\u987a\u5229\u7ed3\u9898\uff0c\u4ee5\u7b2c\u4e00\u4f5c\u8005\u53d1\u88683\u7bc7\u4e00\u533aSCI\u4ee5\u53ca1\u7bc7\u4e8c\u533aSCI\u6587\u7ae0 <\/li>\n    <li>\u73b0\u8d1f\u8d23\u91d1\u65af\u745e\u6297\u4f53\u6d4b\u5e8f\u5e73\u53f0\u4f18\u5316\u4ee5\u53ca\u591a\u6b21\u8de8\u819c\u86cb\u767d\u6297\u4f53\u5f00\u53d1\u9879\u76ee\uff0c\u5df2\u987a\u5229\u5b8c\u6210\u591a\u4f8b\u591a\u6b21\u8de8\u819c\u86cb\u767d\u6297\u4f53\u7684\u5f00\u53d1\uff0c\u5e2e\u52a9\u6d77\u5185\u5916\u5ba2\u6237\u5b9e\u73b0\u4e86\u96be\u5ea6\u9776\u70b9\u7684\u6297\u4f53\u5f00\u53d1\u9700\u6c42\uff0c\u7279\u522b\u662f\u5728mRNA\u514d\u75ab\u6280\u672f\u7528\u4e8e\u591a\u6b21\u8de8\u819c\u86cb\u767d\u6297\u4f53\u7684\u5f00\u53d1\u7b56\u7565\u4e0a\u6709\u7740\u4e30\u5bcc\u7ecf\u9a8c\u3002<\/li>\n     \n<\/ul>\n<\/dd>\n\t\t\t\t<\/dl>\n\t\t\t\t<dl>\n\t\t\t\t\t\n\t\t\t\t<\/dl>\n\t\t\t\t\n\t\t\t<\/div>\n<div class=\"h10\"><\/div>\n<\/div>\n\t<\/article>\n<script>\n    $(document).ready(function() {\t\t\t\t \nif(!$.cookie('GSID')){\n\t$(\".btn-download-2\").show();\n\t$(\".btn-download-1\").hide();\n}else{\n\t$(\".btn-download-1\").show();\n\t$(\".btn-download-2\").hide();\n\n}\n<\/script>","category":"Antibody","application":"mRNA Therapeutics","active":"1","start_time":"2023-09-20 00:00:00","create_date":"2023-10-08 02:32:13","modified_date":"2023-10-08 02:32:29","speaker_name":"\u8096\u5a77\u5a77","featured":"0","region":"ALL","content_sort":"0","dtime":"","template_id":"2231","time":"00:00:00","has_start":1},{"id":"235","loc_code":"CN","name":"\u975e\u75c5\u6bd2\u57fa\u56e0\u7f16\u8f91\u7cfb\u7edf\u5728GCT\u9886\u57df\u7684\u7814\u7a76\u8fdb\u5c55 - \u91d1\u65af\u745e","speaker":"Yijun Guo \u91d1\u65af\u745e\u7814\u53d1\u9ad8\u7ea7\u79d1\u5b66\u5bb6","short_desc":"\u672c\u6b21\u7f51\u7edc\u7814\u8ba8\u4f1a\u5c06\u56f4\u7ed5\u884c\u4e1a\u7814\u7a76\u8fdb\u5c55\uff0c\u7ed3\u5408\u6848\u4f8b\u5206\u4eab\u548c\u4e92\u52a8\u7b54\u7591\u7b49\u65b9\u5f0f\u5c55\u5f00\u7814\u8ba8\u4e3a\u60a8\u5e26\u6765\u975e\u75c5\u6bd2\u7ec6\u80de\u7597\u6cd5\u4ece\u53d1\u73b0\u5230\u4e34\u5e8a\u4e00\u7ad9\u5f0f\u89e3\u51b3\u65b9\u6848\u3002","image":"\/gsimages\/webinar\/research-progress-on-non-viral-gene-editing-systems-328.jpg","small_img":"\/gsimages\/webinar\/research-progress-on-non-viral-gene-editing-systems-100.jpg","alias":"\/webinars\/research-progress-on-non-viral-gene-editing-systems.html","metadata":"<link rel=\"canonical\" href=\"\/\/m.wivlo.com\/webinars\/research-progress-on-non-viral-gene-editing-systems.html\">\n<meta name=\"description\" content=\"\u91d1\u65af\u745e\u8bda\u9080\u60a8\u53c2\u52a0\u975e\u75c5\u6bd2\u57fa\u56e0\u7f16\u8f91\u7cfb\u7edf\u5728GCT\u9886\u57df\u7684\u7814\u7a76\u8fdb\u5c55\u7f51\u7edc\u7814\u8ba8\u4f1a\uff0c\u4e3a\u60a8\u5e26\u6765\u57fa\u56e0\u4e0e\u7ec6\u80de\u6cbb\u7597\u4ece\u53d1\u73b0\u5230\u4e34\u5e8a\u4e00\u7ad9\u5f0f\u89e3\u51b3\u65b9\u6848\u3002\">\n<meta name=\"keywords\" content=\"\u975e\u75c5\u6bd2\u57fa\u56e0, \u57fa\u56e0\u7f16\u8f91, \u7ec6\u80de\u7597\u6cd5, \u975e\u75c5\u6bd2\u7ec6\u80de\u7597\u6cd5\">","content":"{literal}\n<style type=\"text\/css\">\n.blog-content-flex {\n    position: relative;\n    display: flex;\n    flex-flow: wrap;\n    justify-content: space-between;\n}\n.post-region{\nwidth:30%;\n}\n\n@media only screen and (max-width:767px) {\n\n.post-region{\nwidth:100%;\nmargin-bottom:10px;\n}\n}\n<\/style>\n{\/literal}\n<div class=\"webinars-main clearfix\">\n\t<article class=\"webinars-l\">\n\t\t<div class=\"webinars-full\">\n\t\t\t<h1>\u975e\u75c5\u6bd2\u57fa\u56e0\u7f16\u8f91\u7cfb\u7edf\u5728GCT\u9886\u57df\u7684\u7814\u7a76\u8fdb\u5c55<\/h1>\n\t\t\t<p>\u57fa\u56e0\u4e0e\u7ec6\u80de\u6cbb\u7597\u662f\u8fd1\u5e74\u5728\u533b\u5b66\u548c\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u65b0\u661f\uff0c\u5176\u5de8\u5927\u7684\u5e02\u573a\u589e\u957f\u4e5f\u53cd\u6620\u51fa\u8be5\u9886\u57df\u7684\u524d\u666f\u5728\u4e0d\u65ad\u6269\u5927\uff0c\u8fd9\u4e9b\u521b\u65b0\u7597\u6cd5\u5c06\u628a\u751f\u7269\u5236\u836f\u7684\u53d1\u5c55\u5e26\u5230\u4e00\u4e2a\u5168\u65b0\u7684\u6c34\u5e73\uff0c\u5728\u764c\u75c7\u548c\u9057\u4f20\u6027\u75be\u75c5\u7684\u6cbb\u7597\u4e2d\u53d1\u6325\u5de8\u5927\u7684\u6f5c\u529b\u3002<\/p>\n\t\t\t<p>\u975e\u75c5\u6bd2\u7ec6\u80de\u7597\u6cd5\u5f00\u53d1\u5177\u5907\u5b89\u5168\u3001\u5feb\u901f\u3001\u6210\u672c\u53ef\u63a7\u7684\u4f18\u52bf\u3002\u73b0\u9636\u6bb5\uff0c\u7ec6\u80de\u7597\u6cd5\u4ea7\u54c1\u7531\u4e8e\u75c5\u6bd2\u8f7d\u4f53\u77ed\u7f3a\u5bfc\u81f4\u4ea7\u80fd\u53d7\u9650\u7684\u95ee\u9898\u9010\u6e10\u663e\u73b0\uff0c\u800c\u975e\u75c5\u6bd2\u7ec6\u80de\u7597\u6cd5\u7b56\u7565\u6709\u671b\u6210\u4e3a\u63d0\u5347\u7ec6\u80de\u7597\u6cd5\u53ef\u53ca\u6027\u53ca\u5546\u4e1a\u5316\u80fd\u529b\u7684\u65b0\u601d\u8def\u3002<\/p>\n<a class=\"anchor\" name=\"video\"><\/a>\n<h2>\u672c\u6b21\u76f4\u64ad\u7814\u8ba8\u4f1a\uff0c\u60a8\u5c06\u4e86\u89e3\u5230\uff1a<\/h2> \n<ul class=\"tableul tableol\">\n<li>\u975e\u75c5\u6bd2\u4f53\u7cfb\u57fa\u56e0\u7f16\u8f91\u7cfb\u7edf\u7684\u7c7b\u578b\u548c\u7814\u7a76\u8fdb\u5c55<\/li>\n<li>\u975e\u75c5\u6bd2\u4f53\u7cfb\u5728\u57fa\u56e0\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u4e2d\u7684\u5e94\u7528\u4f18\u52bf<\/li>\n<li>\u91d1\u65af\u745e\u7684\u4e00\u7ad9\u5f0f\u57fa\u56e0\u7f16\u8f91\u4ea7\u54c1\u670d\u52a1\u52a9\u529b\u836f\u7269\u4ece\u5f00\u53d1\u5230\u5546\u4e1a\u5316<\/li> \n<\/ul> \n<div class=\"h20\"><\/div>\n<div class=\"h20\"><\/div>\n<div class=\"module-center\">\n\t\t\t\t<iframe class=\"iframe-size\"  src=\"https:\/\/playback-tc.videocc.net\/polyvlive\/fcc00c695576678020283247246\/recordclip-20230823094838-5f3c7f.mp4\" scrolling=\"no\" border=\"0\" frameborder=\"no\" framespacing=\"0\" allowfullscreen=\"true\"> <\/iframe> \n<a href=\"\/customer\/login?return=\/webinars\/research-progress-on-non-viral-gene-editing-systems.html\" class=\"vedio iframe-vedio btn-download-2\"><\/a>\n\t\t\t<\/div>\n<div class=\"h10\"><\/div>\n\t\t\t<div class=\"webinardl\" style=\"overflow:hidden\">\n\t\t\t\t<hr\/>\n\t\t\t\t <img src=\"\/gsimages\/webinar\/research-progress-on-non-viral-gene-editing-systems-speaker.png\" style=\"max-width:130px;border-radius:50%;margin-bottom:0\" class=\"floatR ifn\"> \n\t\t\t\t<dl>\n\n\t\t\t\t\t<dt><strong class=\"font16\">\u4e3b\u8bb2\u4eba\uff1a<\/strong>Yijun Guo, \u91d1\u65af\u745e\u7814\u53d1\u9ad8\u7ea7\u79d1\u5b66\u5bb6\n<\/dt> \n <dd>\n \n<ul class=\"tableul\">\n    <li>\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\/\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66-\u9999\u69df\u5206\u6821\u535a\u58eb<\/li>\n    <li>12\u7bc7\u9ad8IF SCI\u6587\u7ae0\uff0c5\u7bc7\u4e00\u4f5c\u6587\u7ae0 <\/li>\n    <li>10\u5e74+\u7cbe\u51c6\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7814\u7a76\u4e0e\u4f18\u5316\u79d1\u7814\u7ecf\u5386 <\/li>\n    <li>\u4e13\u6ce8\u4e8e\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5728\u57fa\u56e0\u7ec6\u80de\u7597\u6cd5\u4e0a\u7684\u5e94\u7528\u4e0e\u62d3\u5c55 <\/li>\n<\/ul>\n<\/dd>\n\t\t\t\t<\/dl>\n\t\t\t\t<dl>\n\t\t\t\t\t\n\t\t\t\t<\/dl>\n\t\t\t\t\n\t\t\t<\/div>\n<div class=\"h10\"><\/div>\n<\/div>\n\t<\/article>\n<script>\n    $(document).ready(function() {\t\t\t\t \nif(!$.cookie('GSID')){\n\t$(\".btn-download-2\").show();\n\t$(\".btn-download-1\").hide();\n}else{\n\t$(\".btn-download-1\").show();\n\t$(\".btn-download-2\").hide();\n\n}\n<\/script>","category":"CRISPR","application":"Genome Editing","active":"1","start_time":"2023-08-31 00:00:00","create_date":"2023-08-31 03:36:41","modified_date":"2023-08-31 03:36:41","speaker_name":"Yijun Guo","featured":"0","region":"ALL","content_sort":"0","dtime":"","template_id":"2231","time":"00:00:00","has_start":1}],"learning_center":{"id":"50","loc_code":"CN","title":"\u4e00\u79cd\u53ef\u5feb\u901f\u7b5b\u67e5\u51a0\u72b6\u75c5\u6bd2\u662f\u5426\u5177\u6709\u611f\u67d3\u6027\u7684\u65b9\u6cd5","image":"\/gsimages\/res\/a-method-for-quickly-screening-whether-coronavirus-is-infectious-328.jpg","cover_img":"\/gsimages\/res\/a-method-for-quickly-screening-whether-coronavirus-is-infectious-100.jpg","alias":"\/learning-center\/a-method-for-quickly-screening-whether-coronavirus-is-infectious.html","short_desc":"","label":"Research Digest","category":"Other","application":"COVID-19","metadata":"<link rel=\"canonical\" href=\"\/\/m.wivlo.com\/learning-center\/a-method-for-quickly-screening-whether-coronavirus-is-infectious.html\">","content":"{literal}\n<style>\n\n.research-img-module{\n    margin:30px 0;\n    position:relative;\n    text-align:center;\n}\n.module-img {\n    max-width:80%;\n    margin-bottom:15px;\n}\n.module-text{\n    max-width:80%;\n    margin:0px auto;\n}\n.text-gray {\n    color: #aaaaaa;\n}\n<\/style>\n{\/literal}\n<div class=\"news-main clearfix\">\n<article class=\"news-l\">\n <div class=\"news-full\">\n<h1 class=\"top-zero\">\u4e00\u79cd\u53ef\u5feb\u901f\u7b5b\u67e5\u51a0\u72b6\u75c5\u6bd2\u662f\u5426\u5177\u6709\u611f\u67d3\u6027\u7684\u65b9\u6cd5<\/h1>\n\n<p>2003\u5e74\uff0c\u6025\u6027\u547c\u5438\u9053\u7efc\u5408\u75c7\u76f8\u5173\u7684\u51a0\u72b6\u75c5\u6bd2\uff08SARS-CoV\uff09\u4ece\u52a8\u7269\u8eab\u4e0a\u4f20\u64ad\u5230\u4eba\u7c7b\u8eab\u4e0a\uff0c\u5bfc\u81f4\u4e86\u81f4\u547d\u6027\u7684\u547c\u5438\u9053\u75be\u75c5\u3002\u5168\u7403\u75c5\u6bd2\u5b66\u9879\u76ee\u5df2\u7ecf\u5728\u4e0d\u540c\u7684\u52a8\u7269\u548c\u5730\u7406\u533a\u57df\u53d1\u73b0\u5e76\u516c\u5e03\u6570\u5343\u79cd\u7684\u51a0\u72b6\u75c5\u6bd2\u5e8f\u5217\u3002\u03b2\u51a0\u72b6\u75c5\u6bd2\uff08betacoronaviruses\uff09\u662f\u51a0\u72b6\u75c5\u6bd2\u7684\u4e00\u4e2a\u5c5e, \u53ef\u5206\u4e3aABCD\u578b\u3002\u5176\u4e2d\uff0cSARS\u75c5\u6bd2\uff08SARS-CoV\uff09\u548c\u65b0\u51fa\u73b0\u7684\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff08SARS-CoV-2\uff09\u5c5e\u4e8eB\u578b\u3002\u76ee\u524d\uff0c\u6bcf\u5e74\u90fd\u4f1a\u6709\u66f4\u591a\u7684\u51a0\u72b6\u75c5\u6bd2\u5e8f\u5217\u88ab\u53d1\u73b0\uff0c\u4f46\u7531\u4e8e\u7814\u7a76\u51a0\u72b6\u75c5\u6bd2\u7684\u73b0\u6709\u6280\u672f\u5b58\u5728\u8017\u65f6\u3001\u8d39\u7528\u9ad8\u7b49\u95ee\u9898\uff0c\u5173\u4e8e\u8fd9\u4e9b\u75c5\u6bd2\u5bf9\u4eba\u7c7b\u7684\u611f\u67d3\u6027\u7684\u673a\u7406\u7814\u7a76\u4ecd\u5904\u4e8e\u521d\u671f\u9636\u6bb5\u3002\u75c5\u6bd2\u4fb5\u5165\u5bbf\u4e3b\u7ec6\u80de\u662f\u8de8\u7269\u79cd\u4f20\u64ad\u7684\u5173\u952e\u56e0\u7d20\uff0c\u6240\u6709\u7684\u51a0\u72b6\u75c5\u6bd2\u90fd\u7f16\u7801\u4e00\u79cd\u8868\u9762\u86cb\u767d\uff1a\u523a\u7a81\u86cb\u767d\uff0c\u5b83\u80fd\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u53d7\u4f53\u7ed3\u5408\uff0c\u4ecb\u5bfc\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u3002\u5bf9\u4e8e\u03b2\u51a0\u72b6\u75c5\u6bd2\u6765\u8bf4\uff0c\u523a\u7a81\u86cb\u767d\u7684\u53d7\u4f53\u7ed3\u5408\u57df\uff08Receptor binding domain\uff0cRBD\uff09\u53c2\u4e0e\u4e86\u5bbf\u4e3b\u53d7\u4f53\u7684\u8bc6\u522b, \u4ece\u800c\u4fc3\u8fdb\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u3002\u57fa\u4e8e\u6b64\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u9662\u7684\u7814\u7a76\u56e2\u961f\u5728<em>Nature Microbiology<\/em>\u6742\u5fd7\u53d1\u8868\u7684<em>Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses<\/em>\u6587\u7ae0\uff0c\u62a5\u9053\u4e86\u4e00\u79cd\u53ef\u4ee5\u5feb\u901f\u6d4b\u8bd5\u03b2\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u6027\u7684\u65b9\u6cd5\uff0c\u7814\u7a76\u901a\u8fc7\u68c0\u6d4b\u4e86B\u578b\u03b2\u51a0\u72b6\u75c5\u6bd2\u6240\u6709\u5df2\u53d1\u8868\u7684RBD\u7684\u53d7\u4f53\u7ed3\u5408\u60c5\u51b5\uff0c\u786e\u5b9a\u51faSARS-CoV-2\u53ef\u4ee5\u901a\u8fc7\u4e0eACE2\u53d7\u4f53\u8bc6\u522b\u8fdb\u5165\u4eba\u4f53\u7ec6\u80de\uff08Fig. 1a\uff09\u3002<\/p>\n<div class=\"research-img-module\">\n    <img src=\"\/gsimages\/res\/a-method-for-quickly-screening-whether-coronavirus-is-infectious-2.jpg\" class=\"module-img\" >\n    <p class=\"module-center module-text\"><span class=\"text-gray font12\">\u56fe\uff1aFig. 1A<\/span><\/p>\n<\/div>\n<p>B\u578b\u51a0\u72b6\u75c5\u6bd2\u768429\u79cdRBD \u5e8f\u5217\u53ef\u4ee5\u5206\u4e3a\u4e09\u7c7b\uff1a\u5206\u652f1\uff0c\u5206\u652f2\uff0c\u5206\u652f3\uff0cSARS-CoV\u5c5e\u4e8e\u5206\u652f1\u3002\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u5c06\u6240\u6709B\u578b\u51a0\u72b6\u75c5\u6bd2\u7684RBD\u5e8f\u5217\u53d6\u4ee3SARS-CoV\u7684RBD\u5e8f\u5217\uff0c\u6784\u5efa\u51fa\u523a\u7a81\u5d4c\u5408\u8868\u8fbe\u8f7d\u4f53\uff0c\u968f\u540e\u901a\u8fc7\u7ed3\u5408\u523a\u7a81\u5d4c\u5408\u8868\u8fbe\u8f7d\u4f53\u6784\u5efa\u51fa\u6c34\u75b1\u6027\u53e3\u708e\uff08vesicular stomatitis virus \uff0cVSV\uff09\u4f2a\u75c5\u6bd2\u62a5\u544a\u56e0\u5b50\uff08Fig. 1b\uff0c1c\uff09\u3002\u5229\u7528\u542b\u6709\u4e0d\u540cRBD\u7684\u6c34\u75b1\u6027\u53e3\u708e\u4f2a\u75c5\u6bd2\u53bb\u611f\u67d3\u8868\u8fbeACE2\u53d7\u4f53\u7684\u5e7c\u9f20\u80be\u810f\u7ec6\u80de(BHK)\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u4e09\u7c7bRBD\u4e2d\uff0c\u53ea\u6709\u5c5e\u4e8e\u5206\u652f1\u7684SARS-CoV\u53ef\u4ee5\u901a\u8fc7\u4eba\u4f53ACE2\u53d7\u4f53\u8fdb\u5165\u7ec6\u80de\uff08Fig. 1d\uff0c1e\uff09\u3002<\/p>\n<p>\u4e0e\u5bbf\u4e3b\u53d7\u4f53\u7ed3\u5408\u540e\uff0c\u5bbf\u4e3b\u7ec6\u80de\u86cb\u767d\u9176\u5206\u89e3\u523a\u7a81\u86cb\u767d\u91ca\u653e\u51fa\u878d\u5408\u80bd\uff0c\u75c5\u6bd2\u5f97\u4ee5\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u3002\u5bbf\u4e3b\u7ec6\u80de\u86cb\u767d\u9176\u7684\u7f3a\u5931\u6216\u5bbf\u4e3b\u7ec6\u80de\u4e0e\u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u4e4b\u95f4\u7684\u4e0d\u4eb2\u548c\u6027\u90fd\u53ef\u963b\u65ad\u75c5\u6bd2\u7684\u8fdb\u5165\u3002\u7814\u7a76\u4e2d\u5728\u6ca1\u6709\u5916\u6e90\u6027\u86cb\u767d\u9176\u7684\u60c5\u51b5\u4e0b\uff0c\u53ea\u6709B\u578b\u5206\u652f1\u7c7b\u51a0\u72b6\u75c5\u6bd2\u53ef\u4ee5\u611f\u67d3\u975e\u6d32\u7eff\u7334\u80be\u7ec6\u80de\uff0c\u4eba\u7c7b\u80c3\u80a0\u9053\u7ec6\u80de\u3001\u4eba\u7c7b\u809d\u810f\u7ec6\u80de\u548c\u732a\u80be\u7ec6\u80de\u3002\u5916\u6e90\u6027\u86cb\u767d\u9176\u5904\u7406\u6784\u5efa\u7684\u4f2a\u75c5\u6bd2\u540e\u518d\u611f\u67d3\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u3001\u8759\u8760\u548c\u4eba\u7c7b\u7ec6\u80de\uff0c\u5206\u652f2\u7684\u51a0\u72b6\u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u5d4c\u5408\u4f53\u4e5f\u53ef\u4ee5\u611f\u67d3\u5bbf\u4e3b\u7ec6\u80de\uff08Fig. 2\uff09\u3002<\/p>\n\uff08Fig. 1a\uff09\u3002<\/p>\n<div class=\"research-img-module\">\n    <img src=\"\/gsimages\/res\/a-method-for-quickly-screening-whether-coronavirus-is-infectious-3.jpg\" class=\"module-img\" >\n    <p class=\"module-center module-text\"><span class=\"text-gray font12\">\u56fe\uff1aFig. 2<\/span><\/p>\n<\/div>\n<p>\u7814\u7a76\u8fd8\u6d4b\u8bd5\u4e86\u4eba\u4f53\u7684\u03b2\u51a0\u72b6\u75c5\u6bd2\u53d7\u4f53-ACE2 \u3001\u03b1\u51a0\u72b6\u75c5\u6bd2\u53d7\u4f53N-APN \u548cMERS\u75c5\u6bd2\u53d7\u4f53-DPP4\u4ecb\u5bfc\u5206\u652f2\u548c\u5206\u652f3\u7684\u523a\u7a81\u86cb\u767d\u5d4c\u5408\u4f53\u8fdb\u5165\u7ec6\u80de\u7684\u80fd\u529b\uff08Fig. 3a\uff09\u3002\u901a\u8fc7\u86cb\u767d\u9176\u5904\u7406\u8868\u8fbe\u53d7\u4f53\u7684\u7ec6\u80de\uff0c\u53ef\u589e\u5f3aB\u578b-\u5206\u652f 1\u7c7b\u51a0\u72b6\u75c5\u6bd2 RBDs\u8fdb\u5165\u8868\u8fbeACE2\u53d7\u4f53\u7ec6\u80de\u7684\u80fd\u529b\uff0c\u800cDPP4\u53d7\u4f53\u4ec5\u4ecb\u5bfcC\u578b\u51a0\u72b6\u75c5\u6bd2MERS-CoV\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\uff0cAPN\u4ec5\u4ecb\u5bfc\u03b1\u51a0\u72b6\u75c5\u6bd2HCoV-229E\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u3002\u5728\u6ca1\u6709\u53d7\u4f53\u7684\u60c5\u51b5\u4e0b\uff0c\u6240\u6709\u7684\u523a\u7a81\u86cb\u767d\u5d4c\u5408\u4f53\u5747\u65e0\u6cd5\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\uff0c\u8fd9\u8868\u660e\u86cb\u767d\u9176\u4ecb\u5bfc\u7684\u75c5\u6bd2\u4fb5\u67d3\u7ec6\u80de\u4f9d\u8d56\u4e8e\u7279\u5f02\u6027\u53d7\u4f53\uff08Fig. 2b\uff09\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u5408\u6210\u4e86\u8fd1\u671f\u7206\u53d1\u7684B\u578b\u51a0\u72b6\u75c5\u6bd2SARS-CoV-2\u7684RBD\u57fa\u56e0\u5e8f\u5217\uff0c\u5e76\u5229\u7528\u5df2\u77e5\u7684\u4eba\u4f53\u51a0\u72b6\u75c5\u6bd2\u53d7\u4f53\u5bf9\u5176\u8fdb\u884c\u6d4b\u8bd5\u3002\u7ed3\u679c\u8868\u660e\uff0cSARS-CoV-2 \u7684\u523a\u7a81\u86cb\u767d\u4e0e\u5206\u652f1\u7c7b\u7684SARS\u75c5\u6bd2\u8868\u8fbe\u76f8\u4f3c\uff0cSARS-CoV-2\u75c5\u6bd2\u80fd\u591f\u5229\u7528\u4eba\u4f53ACE2\u53d7\u4f53\u8fdb\u5165\u7ec6\u80de\uff08Fig. 3c, 3d\uff09\u3002<\/p>\n<div class=\"research-img-module\">\n    <img src=\"\/gsimages\/res\/a-method-for-quickly-screening-whether-coronavirus-is-infectious-4.jpg\" class=\"module-img\" >\n    <p class=\"module-center module-text\"><span class=\"text-gray font12\">\u56fe\uff1aFig. 3<\/span><\/p>\n<\/div>\n\n<p>B\u578b\u51a0\u72b6\u75c5\u6bd2\u76843\u7c7bRBD\u5b58\u5728\u5dee\u5f02\u3002\u5176\u4e2d\uff0c\u53ea\u6709\u5206\u652f 1\u7c7b\u7684RBD\u5305\u542b\u4e0e\u4eba\u4f53ACE2\u76f8\u4e92\u8bc6\u522b14\u4e2a\u4f4d\u70b9\uff0c\u8fd9\u4e9b\u4f4d\u70b9\u53ca\u7ed3\u5408\u5904\u7684\u73af\u5f62\u7ed3\u6784\u5728\u5206\u652f2\u548c\u5206\u652f3\u4e2d\u5927\u90e8\u5206\u662f\u7f3a\u5931\u7684\uff08Fig. 4a, 4b\uff09\u3002\u6587\u7ae0\u57283\u4e2a\u5206\u652f\u5171\u6709\u5e8f\u5217\u7684\u57fa\u7840\u4e0a\u8bbe\u8ba1\u4e86\u4e00\u7cfb\u5217RBD\u7a81\u53d8\u4f53\uff0c\u7528\u6765\u786e\u5b9a\u53ef\u4ee5\u8ba9\u5206\u652f2\u548c\u5206\u652f3\u7c7bRBD\u4e0e\u53d7\u4f53ACE2\u7ed3\u5408\u7684\u5173\u952e\u5e8f\u5217\u3002\u5728\u5206\u652f1\u7c7bRBD\u5e8f\u5217\u4e0a\u5f15\u5165\u5206\u652f2\u7c7b\u4e0a\u4e24\u4e2a\u73af\u72b6\u7ed3\u6784\u7684\u7f3a\u5931\uff0c\u53ef\u4ee5\u5bfc\u81f4\u523a\u7a81\u86cb\u767d\u8868\u8fbe\u7684\u964d\u4f4e\uff0c\u65e0\u6cd5\u8fdb\u5165\u7ec6\u80de\uff08Fig. 4c, 4d\uff09\u3002\u5728\u5206\u652f2\u548c\u5206\u652f3\u4e0a\u5f15\u5165\u5206\u652f1\u4e0a\u7684\u73af\u5f62\u7ed3\u6784\u6216\u5f15\u5165\u5206\u652f1\u4e0a\u768414\u4e2a\u4f4d\u70b9\uff0c\u5e76\u4e0d\u80fd\u589e\u52a0RBD\u8fdb\u5165\u7ec6\u80de\u7684\u6982\u7387\uff0c\u800c\u5f15\u5165\u5206\u652f1\u4e0a\u768414\u4e2a\u4f4d\u70b9\u53ca\u5468\u56f4\u7684\u73af\u5f62\u7ed3\u6784\u5e8f\u5217\uff0c\u53ef\u4ee5\u589e\u5f3a\u5206\u652f2\u548c\u5206\u652f3\u7684 RBDs\u8fdb\u5165\u7ec6\u80de\uff08Fig. 4c\uff09\u3002<\/p>\n\n<div class=\"research-img-module\">\n    <img src=\"\/gsimages\/res\/a-method-for-quickly-screening-whether-coronavirus-is-infectious-5.jpg\" class=\"module-img\" >\n    <p class=\"module-center module-text\"><span class=\"text-gray font12\">\u56fe\uff1aFig. 4<\/span><\/p>\n<\/div>\n\n<p>\u5c06\u5206\u652f2\u548c\u5206\u652f3\u7c7b\u523a\u7a81\u86cb\u767d\u5e8f\u5217\u5168\u957f\u5408\u6210\u540e\u4e0e\u6784\u5efa\u7684RBD\u5d4c\u5408\u4f53\u8fdb\u884c\u6bd4\u8f83\u3002\u7814\u7a76\u4e2d\u5bf9\u5206\u652f2\u548c\u5206\u652f3\u7c7b\u523a\u7a81\u86cb\u767d\u5168\u957f\u5e8f\u5217\u8fdb\u884c\u5408\u6210\u540e\uff0c\u7528\u5206\u652f1\u7684RBD\u4fdd\u5b88\u5e8f\u5217\u53d6\u4ee3\u539f\u6709RBD\u5e8f\u5217\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u6240\u6709\u7684\u523a\u7a81\u86cb\u767d\u8868\u578b\u7c7b\u4f3c\uff08Fig 5a, 5b\uff09\u3002\u86cb\u767d\u9176\u5904\u7406\u53ef\u4ee5\u4fc3\u8fdb\u5206\u652f2\u7684RBD\u5d4c\u5408\u4f53\u6216\u523a\u7a81\u86cb\u767d\u5168\u957f\u8fdb\u5165Huh\u7ec6\u80de\uff0c\u4f46\u4e0d\u80fd\u4fc3\u8fdb\u5206\u652f3\u7c7b\u75c5\u6bd2\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u3002\u7efc\u4e0a\u6240\u8ff0\uff0cB\u578b\u7684SARS \u75c5\u6bd2RBD\u5d4c\u5408\u4f53\u8868\u73b0\u51fa\u523a\u7a81\u86cb\u767d\u5168\u957f\u7684\u4fb5\u67d3\u80fd\u529b\uff08Fig.  5c\uff09\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u6d4b\u8bd5\u4e86\u53d7\u4f53\u8bc6\u522b\u548c\u86cb\u767d\u9176\u5904\u7406\u662f\u5426\u5b58\u5728\u8026\u5408\u4f5c\u7528\uff0c\u5206\u652f1\u7c7bRBD\u5e8f\u5217\u53d6\u4ee3\u5206\u652f 2\u548c\u5206\u652f3\u7c7bRBD\u5168\u957f\u5e8f\u5217\u540e\uff0c\u5229\u7528\u86cb\u767d\u9176\u5904\u7406\uff0c\u5206\u652f2\u548c\u5206\u652f3\u7c7b\u523a\u7a81\u86cb\u767d\u53ef\u4ee5\u8fdb\u5165\u7ec6\u80de\uff0c\u8868\u660e\u53d7\u4f53\u8bc6\u522b\u548c\u86cb\u767d\u9176\u5904\u7406\u5b58\u5728\u8026\u5408\u4f5c\u7528\uff08Fig. 5\uff09\u3002<\/p>\n\n<div class=\"research-img-module\">\n    <img src=\"\/gsimages\/res\/a-method-for-quickly-screening-whether-coronavirus-is-infectious-6.jpg\" class=\"module-img\" >\n    <p class=\"module-center module-text\"><span class=\"text-gray font12\">\u56fe\uff1aFig. 5<\/span><\/p>\n<\/div>\n\n\n<\/div>\n\n\n<\/article>\n","active":"1","content_sort":"1","create_date":"2021-12-08 03:46:14","modified_date":"2021-12-08 03:46:14","show_type":"2","template_id":"2229"}}}